a Other considerations in selection of the DAA regimen:
-
Presence of liver dysfunction (eg, elevated bilirubin) as protease inhibitors should be avoided
-
Specific drugs that are contraindicated or not recommended with specific DAA agents, including but not limited to:
-
High-dose antacid therapy (eg, twice daily proton pump inhibitor)
-
Amiodarone (contraindicated with sofosbuvir-inclusive regimens; see prescribing information)
-
Specific statins (eg, atorvastatin)
-
Consideration of immunosuppressive drugs and DAA interactions (see below)
b Dosing is 3 coformulated tablets (glecaprevir [100 mg]/pibrentasvir [40 mg]) taken once daily. Please refer to the prescribing information.
|