Treatment of HCV-Uninfected Transplant Recipients Receiving Organs From HCV-Viremic Donors

Recommendations When Considering Use of HCV-Viremic Donor Organs in HCV-Uninfected Recipients

RECOMMENDED

RATING

Informed consent should include the following elements:

Risk of transmission from an HCV-viremic donor (and with a PHS-defined increased risk donor, the potential risks for other viral infections)
Risk of liver disease if HCV treatment is not available or treatment is unsuccessful
Risk of graft failure
Risk of extrahepatic complications, such as HCV-associated renal disease
Risk of HCV transmission to partner
Benefits, specifically reduced waiting time and possibly lower waiting list mortality
Other unknown long-term consequences (hepatic and extrahepatic) of HCV exposure (even if cure is attained)

I, C

Transplant programs should have a programmatic strategy to:

I, C

Recommendation Regarding Timing of DAA Therapy for HCV-Negative Recipients of HCV-Viremic Liver Transplant
RECOMMENDED	RATING
Early^a treatment with a pangenotypic DAA regimen is recommended when the patient is clinically stable.	II, B
^a Early treatment refers to starting within the first month after liver transplant but preferably within the first week when the patient is clinically stable.

Recommended^a regimens listed by evidence level and alphabetically for: Treatment of HCV-Uninfected Recipients of Liver Grafts from HCV-Viremic Donors
RECOMMENDED	DURATION	RATING
Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg)^b	12 weeks	I, C
Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)	12 weeks	I, C
^a Other considerations in selection of the DAA regimen: Presence of liver dysfunction (eg, elevated bilirubin) as protease inhibitors should be avoided Specific drugs that are contraindicated or not recommended with specific DAA agents, including but not limited to: High-dose antacid therapy (eg, twice daily proton pump inhibitor) Amiodarone (contraindicated with sofosbuvir-inclusive regimens; see prescribing information) Specific statins (eg, atorvastatin) Consideration of immunosuppressive drugs and DAA interactions (see below) ^b Dosing is 3 coformulated tablets (glecaprevir [100 mg]/pibrentasvir [40 mg]) taken once daily. Please refer to the prescribing information.

Recommendation Regarding Timing of DAA Therapy for HCV-Negative Recipients of HCV-Viremic Non-Liver Solid Organ Transplant
RECOMMENDED	RATING
Prophylactic^a/preemptive^b treatment with a pangenotypic DAA regimen is recommended.	II, B
^a Prior to HCV RNA results, typically immediately pre-transplant or day 0 post-transplant ^bDay 0 to within the first week post-transplant, typically as soon as the patient is deemed clinically stable

Recommended^a regimens listed by evidence level and alphabetically for: Treatment of HCV-Uninfected Recipients of Non-Liver Organs from HCV-Viremic Donors
RECOMMENDED	DURATION	RATING
Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg)^b	8 weeks	I, C
Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)	12 weeks	I, C
^a Other considerations in selection of the DAA regimen: Presence of liver dysfunction (eg, elevated bilirubin) as protease inhibitors should be avoided Specific drugs that are contraindicated or not recommended with specific DAA agents, including but not limited to: High-dose antacid therapy (eg, twice daily proton pump inhibitor) Amiodarone (contraindicated with sofosbuvir-inclusive regimens; see prescribing information) Specific statins (eg, atorvastatin) Consideration of immunosuppressive drugs and DAA interactions (see below) ^b Dosing is 3 coformulated tablets (glecaprevir [100 mg]/pibrentasvir [40 mg]) taken once daily. Please refer to the prescribing information.

Last update:

August 27, 2020