Methods Table 3 Abbreviations

ACA

Patient Protection and Affordable Care Act

AFP

alpha-fetoprotein

ALT

alanine aminotransferase

AMP

average manufacturer price

Anti-HBc

hepatitis B core total antibody

Anti-HBs

hepatitis B surface antibody

Anti-HCV

HCV antibody

APRI

AST-to-platelet ratio index

AST

aspartate aminotransferase

AUC

area under the curve

AWP

average wholesale price

BCLC

Barcelona-Clinic liver cancerl

BCRP

breast cancer resistance protein

CBC

complete blood count

CDC

US Centers for Disease Control and Prevention

CEA

cost-effectiveness analysis

CI

confidence interval

CTP

Child-Turcotte-Pugh (see CTP classification table below)

CYP

cytochrome P450 enzyme

DAA

direct-acting antiviral

eGFR

estimated glomerular filtration rate

ESRD

end-stage renal disease

FDA

US Food and Drug Administration

HBsAG

hepatitis B virus surface antigen

HBV

hepatitis B virus

HCC

hepatocellular carcinoma

HCV

hepatitis C virus
(Hepatitis C virus and HCV refer to the virus. Hepatitis C and HCV infection or HCV disease refer to the disease entity.)

HCV RNA

hepatitis C virus ribonucleic acid

HR

hazard ratio

ICER

incremental cost-effectiveness ratio

IDU

injection drug use or user

INR

international normalized ratio

MELD

model for end-stage liver disease

MOUD

medication for opioid use disorder

MSM

men who have sex with men

MTCT

mother-to-child transmission

NASH

nonalcoholic steatohepatitis

NAT

nucleic acid testing

NGS

next generation sequencing

NIH

US National Institutes of Health

NS3

HCV nonstructural protein 3 

NS5A

HCV nonstructural protein 5A

OATP

organic anion-transporting polypeptide 

OR

odds ratio

OS

overall survival

PBM

pharmacy benefit manager

PCR

polymerase chain reaction

P-gp

P-glycoprotein

POC

point of care

PrEP

preexposure prophylaxis

PWID

people who inject drugs

QALY

quality-adjusted life-year

RAS

resistance-associated substitution

RBC

red blood cell(s)

RBV

ribavirin

RGT

response-guided therapy

RR

relative risk

sAg

surface antigen

SSP

syringe service program

SOF

sofosbuvir

SVR12 (or 24 or 48, etc)

sustained virologic response at 12 weeks (or at 24 weeks, or at 48 weeks, etc)

TDF

tenofovir disoproxil fumarate

TSH

thyrotropin (previously thyroid-stimulating hormone)

ULN

upper limit of normal

USPSTF

US Preventive Services Task Force

VCTE

vibration-controlled transient liver elastography

WAC

wholesale acquisition cost^b

^a “List price” for wholesale pharmacies to purchase drugs
^b Typically, approximately 17% off of AWP