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HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C
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Table of Contents
Test, Evaluate, Monitor
Treatment-Naive Patients
Treatment-Experienced Patients
Unique & Key Populations
About the Guidance
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Table of Contents
Introduction
Methods
Methods Table 1
Methods Table 2
Methods Table 3 Abbreviations
References
Test, Evaluate, Monitor
Testing and Linkage to Care
When and in Whom
Cost, Reimbursement, and Cost-Effectiveness
Monitoring
Incomplete Adherence
HCV Resistance
Treatment-Naive
Simplified: No Cirrhosis
Simplified: Comp. Cirrhosis
Decompensated Cirrhosis
Genotype 1
GT1a: No Cirrhosis
GT1a: Compensated
GT1b: No Cirrhosis
GT1b: Compensated
Genotype 2
GT2 : No Cirrhosis
GT2 : Compensated
Genotype 3
GT3 : No Cirrhosis
GT3 : Compensated
Genotype 4
GT4 : No Cirrhosis
GT4 : Compensated
Genotype 5 or 6
Treatment-Experienced
SOF-Based and ELB/GRZ Treatment Failures
G/P Treatment Failures
Multiple DAA Treatment Failures
Decompensated Cirrhosis
Unique & Key Populations
HIV/HCV Coinfection
Decompensated Cirrhosis
Post Liver Transplant
Organs from HCV-Viremic Donors
Renal Impairment
Kidney Transplant
Acute Infection
HCV in Pregnancy
HCV in Children
PWID, MSM & Corrections
People Who Inject Drugs
Men Who Have Sex With Men
Correctional Settings
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References
References
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Wyles, David
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Wyles D, Bräu N, Kottilil S, et al.
Sofosbuvir and velpatasvir for the treatment of HCV in patients coinfected with HIV-1: an open-label, phase 3 study
.
Clin Infect Dis
. 2017;65(1):6-12.
Wyles D, Mangia A, Cheng W, et al.
Long-term persistence of HCV NS5A resistance associated substitutions after treatment with the HCV NS5A inhibitor, ledipasvir, without sofosbuvir [Epub ahead of print]
.
Antiviral Therapy
. 2017.
Wyles D, Poordad F, Wang S, et al.
Glecaprevir/pibrentasvir for hepatitis C virus genotype 3 patients with cirrhosis and/or prior treatment experience: a partially randomized phase 3 clinical trial: viral hepatitis
.
Hepatology
. 2018;67(2):514-523.
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