Table 3. Commonly Used Abbreviations

Abbreviation	Definition and Notes
ACA	Patient Protection and Affordable Care Act
AFP	alpha-fetoprotein
ALT	alanine aminotransferase
AMP	average manufacturer price
Anti-HCV	HCV antibody
APRI	AST-to-platelet ratio index
AST	aspartate aminotransferase
AUC	area under the curve
AWP	average wholesale price^a
BOC	boceprevir
CBC	complete blood count
CDC	Centers for Disease Control and Prevention
CEA	cost-effectiveness analysis
CTP	Child-Turcotte-Pugh (see below)
CYP	cytochrome P450
DAA	direct-acting antiviral
eGFR	estimated glomerular filtration rate
ESRD	end-stage renal disease
FDA	US Food and Drug Administration
GFR	glomerular filtration rate
HBsAg	hepatitis B virus surface antigen
HBV	hepatitis B virus
HCC	hepatocellular carcinoma
HCV	hepatitis C virus Hepatitis C virus and HCV refer to the virus. Hepatitis C and HCV infection or HCV disease refer to the disease entity.
ICER	incremental cost-effectiveness ratio
IDU	injection drug use or user
INR	international normalized ratio
MELD	model for end-stage liver disease
MSM	men who have sex with men
NASH	nonalcoholic steatohepatitis
NAT	nucleic acid testing
NIH	National Institutes of Health
NS3	HCV nonstructural protein 3
NS5A	HCV nonstructural protein 5A
OATP	organic anion-transporting polypeptide
PBM	pharmacy benefit manager
PCR	polymerase chain reaction
P-gp	P-glycoprotein
PreP	preexposure prophylaxis
PWID	people who inject drugs
QALY	quality-adjusted life-year
RAS	resistance-associated substitution
RBC	red blood cell(s)
RBV	ribavirin
RGT	response-guided therapy
sAg	surface antigen
SMV	simeprevir
SOF	sofosbuvir
SVR12 (or 24 or 48, etc)	sustained virologic response at 12 weeks (or at 24 weeks, or at 48 weeks, etc)
TSH	thyroid-stimulating hormone
TVR	telaprevir
ULN	upper limit of normal
USPSTF	US Preventive Services Task Force
WAC	wholesale acquisition cost^b
^a “List price” for wholesale pharmacies to purchase drugs ^b Typically, approximately 17% off of AWP

Child-Turcotte-Pugh (CTP) Classification of the Severity of Cirrhosis
	CLASS A	CLASS B	CLASS C
Total Points	5-6	7-9	10-15
Factor	1 Point	2 Points	3 Points
Total bilirubin (µmol/L)	<34	34-50	>50
Serum albumin (g/L)	>35	28-35	<28
Prothrombin time / international normalized ratio	<1.7	1.71-2.3	>2.3
Ascites	None	Mild	Moderate to Severe
Hepatic encephalopathy	None	Grade I-II (or supressed with medication)	Grade III-IV (or refractory)

Table 3. Commonly Used Abbreviations

Abbreviation

Definition and Notes

Child-Turcotte-Pugh (CTP) Classification of the Severity of Cirrhosis