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INTRODUCTION
METHODS

The Guidance was developed by a panel of HCV experts in the fields of hepatology and infectious diseases, using an evidence-based review of information that is largely available to healthcare...

Methods Table 1. Summary of the Process and Methods for the Guidance Development
Methods Table 2. Grading System Used to Rate the Level of the Evidence and Strength of the Recommendation for Each Recommendation

Recommendations are based on scientific evidence and expert opinion.

Methods Table 3. Commonly Used Abbreviations and Their Expansions
HCV TESTING AND LINKAGE TO CARE

A summary of recommendations for Testing and Linkage to Care is found in the BOX.

Testing and Linkage to Care Box: Summary of Recommendations for Testing and Linkage to Care
Testing and Linkage to Care Table 1. FDA-approved, Commercially Available Anti-HCV Screening Assays
Testing and Linkage to Care Table 2. Measures to Prevent Transmission of HCV
Testing and Linkage to Care Table 3: Common Barriers to HCV Treatment and Potential Strategies
Testing and Linkage to Care Figure 1. CDC Recommended Testing Sequence for Identifying Current HCV Infection
WHEN AND IN WHOM TO INITIATE HCV THERAPY

Successful hepatitis C treatment results in sustained virologic response (SVR), which is tantamount to virologic cure,...

When and in Whom to Initiate HCV Therapy Box. Summary of Recommendations for When and in Whom to Initiate HCV Therapy
INITIAL TREATMENT OF HCV INFECTION IN PATIENTS STARTING TREATMENT

Complete revision made on this section on December 19, 2014.

Initial Treatment Box. Summary of Recommendations for Patients Who are Initiating Therapy for HCV Infection or Who Experienced Relapse after Prior PEG/RBV Therapy, by HCV Genotype
RETREATMENT OF PERSONS IN WHOM PRIOR THERAPY HAS FAILED

Complete revision made to this section on December 19, 2014.

Retreatment Box. Summary of Recommendations for Patients in Whom Previous Treatment Has Failed
MONITORING PATIENTS WHO ARE STARTING HEPATITIS C TREATMENT, ARE ON TREATMENT, OR HAVE COMPLETED THERAPY

Complete revision made on this section on December 19, 2014.

Monitoring Box. Summary of the Recommendations for Monitoring Patients Who Are Starting HCV Treatment, Are On Treatment, Or Have Completed Therapy
UNIQUE PATIENT POPULATIONS: PATIENTS WITH HIV/HCV COINFECTION

Complete revision made to this section on December 19, 2014.

Unique Patient Populations: HIV/HCV Coinfection Box. Summary of Recommendations for HIV/HCV-Coinfected Patients Who are Being Treated for HCV, by Genotype
UNIQUE PATIENT POPULATIONS: PATIENTS WITH CIRRHOSIS

Complete revision made on this section on December 19, 2014.

Unique Patient Populations: Cirrhosis Box. Summary of Recommendations for Patients with Cirrhosis
UNIQUE PATIENT POPULATIONS: PATIENTS WHO DEVELOP RECURRENT HCV INFECTION POST–LIVER TRANSPLANTATION

Complete revision made to this section on December 19, 2014.

Unique Patient Populations: Post-Liver Transplantation Box. Summary of Recommendations for Patients Who Develop Recurrent HCV Infection Post-Liver Transplantation
UNIQUE PATIENT POPULATIONS: PATIENTS WITH RENAL IMPAIRMENT, INCLUDING SEVERE RENAL IMPAIRMENT (CREATININE CLEARANCE <30 ML/MIN) OR END-STAGE RENAL DISEASE REQUIRING HEMODIALYSIS OR PERITONEAL DIALYSIS

Complete revision made to this section on December 19, 2014.

Unique Patient Populations: Renal Impairment Box. Summary of Recommendations for Patients with Renal Impairment Including Severe Renal Impairment (CrCl <30 ML/min) or ESRD Requiring Hemodialysis or Peritoneal Dialysis
MANAGEMENT OF ACUTE HCV INFECTION
Acute Box. Recommendations for Management of Acute HCV Infection
Acute Figure. Testing Algorithm for Discrete Recognized Hepatitis C Virus (HCV) Exposure
REFERENCES
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