Table of Contents

INTRODUCTION
METHODS

The Guidance was developed by a panel of HCV experts in the fields of hepatology and infectious diseases, using an evidence-based review of information that is largely available to healthcare...

Methods Table 1. Summary of the Process and Methods for the Guidance Development
Methods Table 2. Rating System Used to Rate the Level of the Evidence and Strength of the Recommendation for Each Recommendation

Recommendations are based on scientific evidence and expert opinion.

Methods Table 3. Commonly Used Abbreviations and Their Expansions
HCV TESTING AND LINKAGE TO CARE

Updated February 24, 2016.

Testing and Linkage to Care Box: Summary of Recommendations for Testing and Linkage to Care

Updated Febraury 24, 2016.

Testing and Linkage to Care Table 1. FDA-approved, Commercially Available Anti-HCV Screening Assays
Testing and Linkage to Care Table 2. Measures to Prevent Transmission of HCV
Testing and Linkage to Care Table 3. Common Barriers to HCV Treatment and Potential Strategies
Testing and Linkage to Care Figure 1. CDC Recommended Testing Sequence for Identifying Current HCV Infection

WHEN AND IN WHOM TO INITIATE HCV THERAPY

Updated February 24, 2016.

When and in Whom to Initiate HCV Therapy Box. Summary of Recommendations for When and in Whom to Initiate HCV Therapy

Updated February 24, 2016.

OVERVIEW OF COST, REIMBURSEMENT, AND COST-EFFECTIVENESS CONSIDERATIONS FOR HEPATITIS C TREATMENT REGIMENS

This section was reviewed and revised February 2016.

INITIAL TREATMENT OF HCV INFECTION

Complete revision made to this section on February 24, 2016.

Initial Treatment Box. Summary of Recommendations for Patients Who are Initiating Therapy for HCV Infection by HCV Genotype

Changes made on February 24, 2016.

RETREATMENT OF PERSONS IN WHOM PRIOR THERAPY HAS FAILED

Complete revision made to this section on February 24, 2016. Changes made on April 25, 2016.

Retreatment Box. Summary of Recommendations for Patients in Whom Previous Treatment Has Failed

Updated February 24, 2016. Changes made on April 25, 2016.

MONITORING PATIENTS WHO ARE STARTING HEPATITIS C TREATMENT, ARE ON TREATMENT, OR HAVE COMPLETED THERAPY

Complete revision made to this section on February 24, 2016.

Monitoring Box. Summary of the Recommendations for Monitoring Patients Who Are Starting HCV Treatment, Are On Treatment, Or Have Completed Therapy

Updated February 24, 2016.

UNIQUE PATIENT POPULATIONS: PATIENTS WITH HIV/HCV COINFECTION

Complete revision made to this section on February 24, 2016. Changes made March 10, 2016.

Unique Patient Populations: HIV/HCV Coinfection Box. Summary of Recommendations for HIV/HCV-Coinfected Patients Who are Being Treated for HCV, by Genotype

Complete revision made to this section on February 24, 2016. Changes made March 10, 2016.

UNIQUE PATIENT POPULATIONS: PATIENTS WITH DECOMPENSATED CIRRHOSIS

Complete revision made to this section on December 19, 2014. Additional changes made on February 24, 2016.

Unique Patient Populations: Cirrhosis Box. Summary of Recommendations for Patients with Decompensated Cirrhosis

Changes made on February 24, 2016.

UNIQUE PATIENT POPULATIONS: PATIENTS WHO DEVELOP RECURRENT HCV INFECTION POST–LIVER TRANSPLANTATION

Changes made on February 24, 2016.

Unique Patient Populations: Post-Liver Transplantation Box. Summary of Recommendations for Patients Who Develop Recurrent HCV Infection Post-Liver Transplantation

Updated February 24, 2016.

UNIQUE PATIENT POPULATIONS: PATIENTS WITH RENAL IMPAIRMENT

Complete revision made to this section on February 24, 2016.

Unique Patient Populations: Renal Impairment Box. Summary of Recommendations for Patients with Renal Impairment Including Severe Renal Impairment (CrCl <30 ML/min) or ESRD Requiring Hemodialysis or Peritoneal Dialysis

Updated February 24, 2016.

MANAGEMENT OF ACUTE HCV INFECTION

Changes made on February 24, 2016.

Acute Box. Recommendations for Management of Acute HCV Infection

Updated February 24, 2016.

Acute Figure. Testing Algorithm for Discrete Recognized Hepatitis C Virus (HCV) Exposure

Reviewed February 2016.

REFERENCES

Updated April 25, 2016.

WEBSITE POLICIES

Reviewed February 2016.