Table 3. Commonly Used Abbreviations and Their Expansions


Expansion or Notes

These terms are not expanded in text
HCV hepatitis C virus. In this Guidance "hepatitis C virus" and HCV refer to the virus. Hepatitis C and HCV infection or HCV disease refer to the resulting disease.
These terms are expanded at first mention in text
AFP Alpha-fetoprotein
ALT alanine aminotransferase
Anti-HCV HCV antibody
APRI AST-to-platelet ratio index
AST aspartate aminotransferase
AUC area under the curve
BOC boceprevir
CBC complete blood cell (eg, complete blood cell count)
CDC Centers for Disease Control and Prevention
CTP Child-Turcotte-Pugh (see below)
DAA direct-acting antiviral
eGFR estimated glomerular filtration rate
ESRD end-stage renal disease
FDA Food and Drug Administration
GFR glomerular filtration rate
HBsAg hepatitis B virus surface antigen
HBV hepatitis B virus
HCC hepatocellular carcinoma
IDU injection drug use or user
INR international normalized ratio
MELD model for end-stage liver disease
MSM men who have sex with men
NASH nonalcoholic steatohepatitis
NAT nucleic acid testing
NIH National Institutes of Health
NS3 HCV nonstructural protein 3 
NS5A HCV nonstructural protein 5A
OATP organic anion-transporting polypeptide
PCR polymerase chain reaction
P-gp P-glycoprotein
PreP preexposure prophylaxis
RAS resistance-associated substitution
RBC red blood cell (eg, red blood cell count)
RBV ribavirin
RGT response-guided therapy
sAg surface antigen
SMV simeprevir; used for the treatment of those with genotype 1 of hepatitis C virus (HCV) who have compensated liver disease, including cirrhosis
SOF sofosbuvir; a nucleoside analogue used in combination with other drugs for the treatment of HCV infection
SVR12 (or 24 or 48, etc) sustained virologic response at 12 weeks (or at 24 weeks, or at 48 weeks, etc)
TSH thyroid-stimulating hormone
TVR telaprevir; an antiviral agent to treat hepatitis C
ULN upper limit of normal
USPSTF US Preventive Services Task Force



Definition of Terms: Child-Turcotte-Pugh (CTP) Classification of the Severity of Cirrhosis

Total Points 5-6 7-9 10-15
Factor 1 Point 2 Points 3 Points
Total bilirubin (µmol/L) <34 34-50 >50
Serum albumin (g/L) >35 28-35 <28
Prothrombin time / international normalized ratio <1.7 1.71-2.3 >2.3
Ascites None Mild Moderate to Severe
Hepatic encephalopathy None Grade I-II (or supressed with medication) Grade III-IV (or refractory)


Last update: 
September 21, 2017