Summary: Patients with Renal Impairment
Recommendation for Patients With CKD Stagea
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RECOMMENDED
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RATING 
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No dose adjustment in direct-acting antivirals is required when using recommended regimens.b
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I, A or IIa, Bc
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a Chronic kidney disease (CKD) stages: 1 = normal (eGFR >90 mL/min); 2 = mild CKD (eGFR 60-89 mL/min); 3 = moderate CKD (eGFR 30-59 mL/min); 4 = severe CKD (eGFR 15-29 mL/min); 5 = end-stage CKD (eGFR <15 mL/min)
b A ribavirin dose reduction may be required for patients with CKD stage 3, 4, or 5; see prescribing information for details.
c The rating is I, A for patients with CKD stage 1, 2, or 3 and IIa, B for those with CKD stage 4 or 5.
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