Summary: Peginterferon/Ribavirin-Experienced, Genotype 3 Patients Without Cirrhosis
Recommended and alternative regimens listed by evidence level and alphabetically for:
Peginterferon/Ribavirin-Experienced, Genotype 3 Patients Without Cirrhosis
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RECOMMENDED
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DURATION
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RATING 
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Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg) for patients without baseline Y93H RAS to velpatasvira
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12 weeks
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I, A
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ALTERNATIVE
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DURATION
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RATING
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Daily fixed-dose combination of glecaprevir (300 mg)/pibrentasvir (120 mg)b
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16 weeks
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IIa, B
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Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg)/voxilaprevir (100 mg) when Y93H is present
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12 weeks
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IIb, B
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a Baseline RAS testing for Y93H is recommended. If the Y93H substitution is identified, an alternative regimen should be used, or weight-based ribavirin should be added.
b Dosing is 3 coformulated tablets (glecaprevir [100 mg]/pibrentasvir [40 mg]) taken once daily. Please refer to the prescribing information.
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